New genetic mapping improves optimal treatment for intrahepatic cholangiocarcinoma
picture: To address this challenge, the team identified low-intratumor heterogeneity/high-intertumor variability (LIHV) genes. This signature of 1,341 genes targets markers that remain consistent within a human tumor but vary greatly between patients. By filtering out the discrepant “noise”, the LIHV design enables a robust and reproducible classification of iCCA into five molecular subtypes, each associated … Read more